• icon Our Efforts
  • icon Our Methods
  • icon Recent Presentations
  • icon News
imageOur EffortsWe are studying the effects of post-translational modification on membrane proteins involved human diseases. We use in vitro glycosylation to study the changes that occur when a sugar group is attached to a protein. Read More
imageOur Methods We use both solution and solid-state NMR to determine the structure, dynamics and interactions of membrane proteins in lipid environments that resemble the membranes of cells. Read More
imageRecent Presentations Rachel Dolan and Emily Forster presented their research at the Undergraduate Research Symposium at the ConocoPhillips OSU Alumni Center on April 19 Read More
imageNews Michael Harris received his PhD in Spring of 2022 after defending his dissertation. Read About This & More
 
bottles

See the Lab

Take a virtual tour of our lab in the Henry Bellmon Research Center

See More

341A2414 cropped

Outreach

Education is an important part of making sure we have future scientists. If you have an outreach need let us know about it.

Contact Us

chemistry pete

Become a Cowboy

Learn more about our graduate program at Oklahoma State University

Learn More

 

 

 

 

The goal of our lab is to use multidisciplines of science; chemistry, biology, biochemistry, and physics, to improve the quality of life for mankind. We believe that we can make a difference with our research.

 

 

 

 

 

 

 

 

 

Selected Publications

in vitro glycosylation of the membrane protein γ-sarcoglycan in nanodiscsACS Omega, 2023 8: 40904-40910Harris, MP, Dolan, RS, Bryce, JR, Ewusi, JG, Cook GA

Abstract

Relationship between cell envelope ultrastructure and the antibacterial properties of a novel hydrophobic eumelanin-inspired derivativeaseFrontiers in Bacteriology, 2023 2: 1-11Reed, DR, Nehmzow, K, Essandoh, MA, Ebqa’ai, MA, Nelson, TL, Lutter, EI, Cook, GA, Champlin, FR

Abstract

Recombinant expresstion, purificaiton, and structural analysis of two ectodomains of Syndecan-1Protein Expression and Purification, 2023 201: 106170Anderson, AR, Cook, GA

Abstract

EF-hand protein, EfhP, specifically binds Ca2+ and mediates Ca2+ regulation of virulence in a human pathogen Pseudomonas aeruginosaACS Scientific Reports, 2022 12: 8791-8805Kayastha, BB, Kubo, A, Burch-Konda, J, Rogers, RR, Dohmen, RL, Bevere, J, Peng, S, Chaudhary, B, Mohanty, S,  Barbier, M, Cook, GA, Deng, J, Patrauchan, MA

Abstract

in vitro Glycosylation of Membrane Proteins Using N-GlycosyltransferaseACS Omega, 2021 6: 12133-12142Liyanage, LA, Harris, MS, Cook, GA

Abstract

Expression, purification and structural analysis of the full-length human integral membrane protein γ-sarcoglycanProtein Expr Purif, 2020 167:105525 Jamaleddine, M, Harris, MS, Liyanage L, Cook GA

Abstract

Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance Biochemistry, 2013, 52:5295-303 Cook GA, Dawson LA, Tian, Y, Opella, SJ

Abstract

'q-Titration' of long-chain and short-chain lipids differentiates between structured and mobile residues of membrane proteins studied in bicelles by solution NMR spectroscopy J Magn Reson, 2012, 214:111-8 Son WS, Park SH, Nothnagel HJ, Lu GJ, Wang Y, Zhang H, Cook GA, Howell SC, Opella SJ

Abstract

Nanodiscs versus macrodiscs for NMR of membrane proteins Biochemistry, 2011, 50:8983-5 Park SH, Berkamp S, Cook GA, Chan MK, Viadiu H, Opella SJ

Abstract

Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore Biochim Biophys Acta, 2012, 1818:1039-48 Bukovnik U1, Gao J, Cook GA, Shank LP, Seabra MB, Schultz BD, Iwamoto T, Chen J, Tomich JM

Abstract

Complete List of Publications